LymphedemaV1, Main, Exploration, bibRecord, 001618

Weight Lifting and Appendicular Skeletal Muscle Mass among Breast Cancer Survivors: A Randomized Controlled Trial

Identifieur interne : 001618 ( Main/Exploration ); précédent : 001617; suivant : 001619

Weight Lifting and Appendicular Skeletal Muscle Mass among Breast Cancer Survivors: A Randomized Controlled Trial

Auteurs : Justin C. Brown ; Kathryn H. Schmitz

Source :

Breast cancer research and treatment [ 0167-6806 ] ; 2015.

RBID : PMC:4596259

Descripteurs français

KwdFr :
- Absorptiométrie photonique, Activité motrice, Adulte d'âge moyen, Composition corporelle, Facteurs de risque, Femelle, Force musculaire, Haltérophilie, Humains, Muscles squelettiques (anatomopathologie), Muscles squelettiques (physiopathologie), Sujet âgé, Survivants, Taille d'organe, Tumeurs du sein (anatomopathologie), Tumeurs du sein (diagnostic), Tumeurs du sein (traitement médicamenteux), Tumeurs du sein (épidémiologie), Études de suivi.
MESH :
- anatomopathologie : Muscles squelettiques, Tumeurs du sein.
- diagnostic : Tumeurs du sein.
- physiopathologie : Muscles squelettiques.
- traitement médicamenteux : Tumeurs du sein.
- épidémiologie : Tumeurs du sein.
- Absorptiométrie photonique, Activité motrice, Adulte d'âge moyen, Composition corporelle, Facteurs de risque, Femelle, Force musculaire, Haltérophilie, Humains, Sujet âgé, Survivants, Taille d'organe, Études de suivi.

English descriptors

KwdEn :
- Absorptiometry, Photon, Aged, Body Composition, Breast Neoplasms (diagnosis), Breast Neoplasms (drug therapy), Breast Neoplasms (epidemiology), Breast Neoplasms (pathology), Female, Follow-Up Studies, Humans, Middle Aged, Motor Activity, Muscle Strength, Muscle, Skeletal (pathology), Muscle, Skeletal (physiopathology), Organ Size, Risk Factors, Survivors, Weight Lifting.
MESH :
- diagnosis : Breast Neoplasms.
- drug therapy : Breast Neoplasms.
- epidemiology : Breast Neoplasms.
- pathology : Breast Neoplasms, Muscle, Skeletal.
- physiopathology : Muscle, Skeletal.
- Absorptiometry, Photon, Aged, Body Composition, Female, Follow-Up Studies, Humans, Middle Aged, Motor Activity, Muscle Strength, Organ Size, Risk Factors, Survivors, Weight Lifting.

Abstract

Purpose

Low appendicular skeletal muscle mass (ASMM) is associated with premature mortality, hyperinsulinemia, frailty, disability, and low bone mineral density. We explored the potential efficacy of slowly-progressive weight lifting to attenuate the decline of ASMM among breast cancer survivors by conducting a post hoc analysis of data from the Physical Activity and Lymphedema trial.

Methods

Between October 2005 and August 2008 we conducted a single-blind, randomized controlled trial of twice-weekly slowly-progressive weight lifting or standard care among 295 non-metastatic breast cancer survivors. ASMM was quantified using dual-energy x-ray absorptiometry. Changes in ASMM were evaluated from baseline to 12-months between the weight lifting and control groups using repeated-measures linear mixed-effects regression models.

Results

Over 12-months, participants in the weight lifting group experienced attenuated declines in muscle mass compared to the control group, as reflected by relative ASMM (−0.01±0.02 kg/m² versus −0.08±0.03 kg/m²; P=0.041) and absolute ASMM (−0.02±0.06 kg versus −0.22±0.07 kg; P=0.038), respectively. Weight lifting did not alter other body composition outcomes including body mass index, total body mass, body fat percentage, and fat mass compared to the control group. Weight lifting significantly increased upper- and lower-body muscle strength compared to the control group. The intervention was well-tolerated with no serious adverse events related to weight lifting.

Conclusions

Slowly-progressive weight lifting attenuated the decline of ASMM among breast cancer survivors compared to standard care over 12-months. These data are hypothesis generating. Future studies should examine the efficacy of weight lifting to improve distal health outcomes among breast cancer survivors.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596259

DOI: 10.1007/s10549-015-3409-0
PubMed: 25935584
PubMed Central: 4596259

Affiliations:

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<term>Facteurs de risque</term>
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<term>Tumeurs du sein (diagnostic)</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">Low appendicular skeletal muscle mass (ASMM) is associated with premature mortality, hyperinsulinemia, frailty, disability, and low bone mineral density. We explored the potential efficacy of slowly-progressive weight lifting to attenuate the decline of ASMM among breast cancer survivors by conducting a post hoc analysis of data from the Physical Activity and Lymphedema trial.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Between October 2005 and August 2008 we conducted a single-blind, randomized controlled trial of twice-weekly slowly-progressive weight lifting or standard care among 295 non-metastatic breast cancer survivors. ASMM was quantified using dual-energy x-ray absorptiometry. Changes in ASMM were evaluated from baseline to 12-months between the weight lifting and control groups using repeated-measures linear mixed-effects regression models.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Over 12-months, participants in the weight lifting group experienced attenuated declines in muscle mass compared to the control group, as reflected by relative ASMM (−0.01±0.02 kg/m<sup>2</sup>
 versus −0.08±0.03 kg/m<sup>2</sup>
; <italic>P</italic>
=0.041) and absolute ASMM (−0.02±0.06 kg versus −0.22±0.07 kg; <italic>P</italic>
=0.038), respectively. Weight lifting did not alter other body composition outcomes including body mass index, total body mass, body fat percentage, and fat mass compared to the control group. Weight lifting significantly increased upper- and lower-body muscle strength compared to the control group. The intervention was well-tolerated with no serious adverse events related to weight lifting.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Slowly-progressive weight lifting attenuated the decline of ASMM among breast cancer survivors compared to standard care over 12-months. These data are hypothesis generating. Future studies should examine the efficacy of weight lifting to improve distal health outcomes among breast cancer survivors.</p>
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Weight Lifting and Appendicular Skeletal Muscle Mass among Breast Cancer Survivors: A Randomized Controlled Trial

Weight Lifting and Appendicular Skeletal Muscle Mass among Breast Cancer Survivors: A Randomized Controlled Trial

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.